The production of thrombopoietin takes place in both the kidney and liver. Its main purpose is to help with the regulation of platelet production. It also acts as a stimulant for megakaryocytes, which are cells found in bone marrow, that produce platelets. THPO is found in different cells within the liver and kidney.
Likewise, what stimulates platelet production?
Thrombopoietin is a glycoprotein hormone produced by the liver and kidney which regulates the production of platelets. It stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets.
Additionally, how many platelets does a megakaryocyte produce?
How often are platelets produced?
thrombopoietin. Each megakaryocyte produces between 5,000 and 10,000 platelets before its cellular components are fully depleted. Altogether, around 10^11 platelets are produced each day in a healthy adult. The average lifespan of a platelet is just 5 to 10 days.
Which organ makes platelets?
The bone marrow makes enough platelets, but the body destroys them or uses them up. The spleen holds on to too many platelets. The spleen is an organ that normally stores about one-third of the body's platelets. It also helps your body fight infection and remove unwanted cell material.