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What is the drug Propulsid used for?

By: Caitlin Nicole McdonaldUpdated: February 13, 2021

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Cisapride is a medication intended only to treat the symptoms of nighttime heartburn in adults. Nocturnal, or nighttime, heartburn is a common symptom of a medical condition called gastroesophageal reflux disease (GERD).
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Also, why is cisapride banned?

Cisapride withdrawn because of cardiac side effects. Cisapride (Prepulsid) has been withdrawn from the UK market until further notice because it has been associated with serious cardiovascular side effects. Product licences for the drug were suspended on July 28.

Also to know, why was Propulsid taken off the market?

On March 23, 2000, the FDA announced that Propulsid would be taken off the market as of July as a normally prescribed drug because of scores of confirmed heart-rhythm deaths.

What does cisapride treat?

Cisapride (brand names: Prepulsid®, Propulsid®) is a medication used to enhance the movement of the gastrointestinal (GI) system to treat conditions such as stasis, reflux, and constipation/megacolon (in cats).

When was Propulsid removed from market?

On March 23, 2000, the FDA announced that Propulsid would be taken off the market as of July as a normally prescribed drug because of scores of confirmed heart-rhythm deaths. Overall, Propulsid has been cited as a suspect in 302 deaths.

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Is Propulsid available in the US?

Janssen Pharmaceutica Inc., of Titusville, N.J., has announced that it has decided to stop marketing cisapride (Propulsid) in the United States as of July 14, 2000.

Can cisapride cause vomiting?

Cisapride is generally well tolerated in cats and dogs. The most common side effects are vomiting, diarrhea or abdominal pain. Changes in heart rhythm are a rare side effect in animals.

Is simethicone a prescription drug?

What Is Simethicone? Simethicone is an over-the-counter (OTC) drug that treats symptoms of gas, which may include painful pressure, fullness, and bloating. The medication is in the antiflatulent class of drugs. It works by changing the surface tension of gas bubbles in the stomach and intestines.

How long does cisapride stay in your system?

This short-acting medication should stop working within 24 hours, although effects can be longer in pets with liver or kidney disease.

Is cisapride a laxative?

Laxative consumption was decreased from 3.6 +/- 0.3 to 1.8 +/- 0.2 doses/week by cisapride (p less than 0.001) and from 3.3 +/- 0.3 to 2.8 +/- 0.3 by placebo (p less than 0.05). It is concluded that cisapride improves bowel habits in patients with idiopathic constipation and reduces laxative consumption.

What is cisapride used for in rabbits?

An intestinal motility agent, such as cisapride (Propulsid) or metoclopramide (Reglan) will help get a static intestine moving again. Both of the aforementioned drugs are safe and effective for rabbits. In severe cases of GI stasis, both drugs can be used simultaneously.

Does cisapride need to be refrigerated?

Five bottles were stored at room temperature (25 +/- 0.1 degrees C) and 5 under refrigeration (4 degrees C). CONCLUSIONS: Cisapride was stable in a suspension for 91 days at 4 degrees C and 28 days at 25 degrees C in amber plastic prescription bottles.

Is aluminum a hydroxide?

Aluminum is a naturally occurring mineral. Aluminum hydroxide is an antacid. Aluminum hydroxide is used to treat heartburn, upset stomach, sour stomach, or acid indigestion. Aluminum hydroxide may also be used for purposes not listed in this medication guide.

Is famotidine a prokinetic?

Cimetidine and famotidine are not acetylcholinesterase inhibitors and do not have prokinetic effects. Ranitidine and nizatidine stimulate GI motility by increasing the amount of acetylcholinesterase available to bind smooth muscle muscarinic cholinergic receptors.

How long does it take for cisapride to work in cats?

It may be given with or without food, but if your pet vomits when dosed on an empty stomach, give future doses with food or a treat. Measure liquid forms of this medication carefully. This medication will take effect quickly, in about 1 to 2 hours, and improvement in clinical signs should follow.

What are the side effects of cisapride in cats?

Side Effects
Cisapride is generally well tolerated in cats and dogs. The most common side effects are vomiting, diarrhea or abdominal pain. Changes in heart rhythm are a rare side effect in animals.

Is cisapride available in Canada?

You may hear cisapride called by its brand name, Propulsid. Cisapride is available as a tablet. SickKids compounds the medication into lower dose capsules. It has been taken off the market in Canada, but can still be obtained through the Health Canada Special Access Program.

Is cisapride available in Australia?

In Australia, the Therapeutic Goods Administration now only approves cisapride for a few indications and the product information carries a boxed warning about the risk of arrhythmia. The listing of cisapride on the Pharmaceutical Benefits Scheme (PBS) is even more restricted.

What is cat Megacolon?

Megacolon is a term used to describe a very dilated, flaccid, incompetent colon. This usually occurs, secondary to chronic constipation and retention of feces, but may be a congenital dysfunction. Idiopathic megacolon is a disease in cats where the colon loses its normal motility and becomes progressively larger.

What do you feed a cat with megacolon?

Recently, Royal Canin launched Feline Gastrointestinal Fiber Response diet, a moderate fiber, psyllium-enriched, extruded dry feline diet that has been clinically proven to help cats with constipation/ obstipation/megacolon.