PLS affects the upper motor neurons alone, while ALS affects the upper and lower motor neurons. In PLS, there is no evi- dence of the degeneration of spinal motor neurons that occurs in ALS. The progress of PLS is more gradual and less devastating than that of ALS.
Then, what are the symptoms of PLS?
Symptoms include weakness, muscle stiffness and spasticity, clumsiness, slowing of movement, and problems with balance and speech. PLS is more common in men than in women, with a varied gradual onset that generally occurs between ages 40 and 60. PLS progresses gradually over a number of years, or even decades.
Additionally, is there a cure for PLS?
There is no cure and the progression of symptoms varies. Some people may retain the ability to walk without assistance, but others eventually require wheelchairs, canes, or other assistive devices. PLS is not fatal. There is no cure and the progression of symptoms varies.
How often does pls turn into ALS?
In another study reviewing charts of 29 patients whose initial presentation in an ALS clinic was consistent with PLS, Gordon and colleagues found that 13 patients subsequently developed an upper motor neuron predominant form of ALS, most within four years after onset of symptoms.
How long can you live with pls?
Although the average progression of primary lateral sclerosis (PLS) lasts around 20 years, the disease has highly variable effects from person to person. Some people continue to walk, but others eventually need to use wheelchairs or other assistive devices.