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What is pazopanib used for?

By: Jeff WheelerUpdated: March 11, 2021

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Pazopanib is used to treat kidney cancer. It may also be used to treat certain other types of cancer (soft tissue sarcoma). Pazopanib belongs to a class of drugs known as tyrosine kinase inhibitors. It works by decreasing the blood supply to the cancer tumor to slow tumor growth.

Keeping this in view, is Pazopanib a chemotherapy?

Pazopanib is not a chemotherapy drug but one of many "targeted therapies." Targeted therapy is the result of about 100 years of research dedicated to understanding the differences between cancer cells and normal cells.

Beside above, how do you take pazopanib?

Pazopanib comes as a tablet to take by mouth. It should be taken without food, on an empty stomach, at least 1 hour before or 2 hours after a meal. Take the tablets whole; do not crush, break or chew. Take pazopanib at around the same time every day.

Does votrient cure cancer?

VOTRIENT may shrink or slow the growth of the cancer by interfering with the function of a protein called vascular endothelial growth factor. VOTRIENT may shrink or slow the growth of kidney cancer for a period of time. VOTRIENT is not a cure for kidney cancer. VOTRIENT is not a chemotherapy drug.

How long can you take pazopanib?

The median time before the cancer progressed was comparable: 8.4 months for pazopanib and 9.5 months for sunitinib. Median overall survival was also similar – 28.4 months for patients taking pazopanib and 29.3 months for sunitinib.

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How much does pazopanib cost?

Pazopanib is a very expensive drug; a one-month supply usually costs around $10,000.

What type of drug is pazopanib?

Drug Type: Pazopanib is a targeted therapy. Pazopanib is classified as a Tyrosine Kinase inhibitor; Vascular Endothelial Growth Factor (VEGF) inhibitor.

How does pazopanib work?

Pazopanib is a type of targeted cancer drug called a tyrosine kinase inhibitor (TKI). Tyrosine kinases are proteins which act as chemical messengers (enzymes) in cells. It stops cancer cells forming blood vessels that they need in order to grow.

Is Stage 4 a sarcoma terminal?

Stage IV soft tissue sarcoma
A sarcoma is considered stage IV when it has spread to distant parts of the body. Stage IV sarcomas are rarely curable. But some patients may be cured if the main (primary) tumor and all of the areas of cancer spread (metastases) can be removed by surgery.

Does votrient shrink tumors?

VOTRIENT works to prevent the growth of new blood vessels to the tumor and may shrink or slow the growth of the cancer by stopping a protein called vascular endothelial growth factor or VEGF (vehj eff). VEGF is important for the growth of blood vessels to supply nutrients to the tumor cells.

Does sarcoma grow fast?

Both fibromatosis and desmoid tumors are usually slow growing and benign, or noncancerous, sarcomas that do not spread. But some can grow fast and become large enough to damage surrounding vital organs, such as the intestines, liver, lungs, and nerves.

Does votrient cause hair loss?

Votrient may cause high blood pressure. Temporary hair loss and/or change in hair or skin color may occur. Normal hair growth should return after treatment with Votrient has ended. Votrient may interact with other drugs that can cause bleeding/bruising such as antiplatelet drugs, NSAIDs, aspirin, or blood thinners.

How effective is Votrient?

The FDA approved Votrient™ (pazopanib) for the treatment of advanced renal cell carcinoma (kidney cancer). The approval of Votrient came after the results of a Phase III trial showed that the drug reduced the risk of tumor progression or death by 54% compared with placebo, regardless of prior treatment.

What are the side effects of Votrient?

The following Votrient side effects are common (occurring in greater than 30%) for patients taking Votrient:
  • Diarrhea.
  • Hypertension.
  • Hair color changes.
  • Low blood counts (low white blood cells, low platelets)
  • Elevated liver function tests (AST, ALT)
  • Elevated bilirubin level.

Is pazopanib an immunotherapy?

Pazopanib is a standard first-line therapy for patients with advanced RCC. The research team evaluated the safety and efficacy of pazopanib plus pembrolizumab, a humanized monoclonal immunoglobulin immunotherapy that targets programmed death 1 receptors.

What is soft tissue sarcoma?

A sarcoma is a type of cancer that starts in tissues like bone or muscle. Bone and soft tissue sarcomas are the main types of sarcoma. Soft tissue sarcomas can develop in soft tissues like fat, muscle, nerves, fibrous tissues, blood vessels, or deep skin tissues. They can be found in any part of the body.

What is Votrient used to treat?

Pazopanib is used to treat kidney cancer. It may also be used to treat certain other types of cancer (soft tissue sarcoma). Pazopanib belongs to a class of drugs known as tyrosine kinase inhibitors. It works by decreasing the blood supply to the cancer tumor to slow tumor growth.

How do you take Votrient?

The recommended starting dose is 800 mg once daily.
  1. VOTRIENT® (pazopanib) tablets is available in 200-mg tablets.
  2. Daily dose should not exceed 800 mg.
  3. VOTRIENT must be taken without food at least 1 hour before or 2 hours after a meal.

Is votrient a chemotherapy drug?

Votrient is not a chemotherapy drug but one of many "targeted therapies." Targeted therapy is the result of about 100 years of research dedicated to understanding the differences between cancer cells and normal cells.