Health & Fitness

What is flumazenil used for?

By: Mike RaceloUpdated: December 26, 2020

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Benzodiazepines are sometimes used as sedatives before surgery or other medical procedures. Flumazenil is used to reverse benzodiazepine sedation to help you wake up after your medical procedure. Flumazenil is also used to treat benzodiazepine overdose in adults.

Considering this, what is the brand name for flumazenil?

Flumazenil is sold under a wide variety of brand names worldwide like Anexate, Lanexat, Mazicon, Romazicon. In India it is manufactured by Roche Bangladesh Pharmaceuticals and USAN Pharmaceuticals.

Furthermore, how do you take flumazenil?

The recommended initial dose of Flumazenil is 0.3 mg i.v. If the required level of consciousness is not obtained within 60 seconds, a further dose of 0.1 mg can be injected and repeated at 60-second intervals, up to a total dose of 2 mg or until the patient awakes.

Can flumazenil cause seizures?

Flumazenil may cause seizures (convulsions), especially in people who have sedative-addiction withdrawal symptoms or recent antidepressant overdose, people who have recently received injectable benzodiazepines, or people who had symptoms of a seizure just before receiving flumazenil.

Is flumazenil safe?

Flumazenil may cause seizures (convulsions), especially: Talk to your doctor if you have concerns about the risk of seizure. You should not receive this medication if you are allergic to flumazenil or any type of benzodiazepine sedative, or if you have taken an overdose of certain antidepressant medication.

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Why does flumazenil cause seizures?

Seizure is a well-known and potential lethal AE to flumazenil. Seizures are not considered to be the result of a direct toxic effect of flumazenil but due to reversal of the anticonvulsant effect of the benzodiazepine in the presence of pro-convulsive drugs or other predispositions to seizures.

What class of drug is flumazenil?

Flumazenil is a benzodiazepine antagonist. It competitively inhibits the activity of benzodiazepine and non-benzodiazepine substances that interact with benzodiazepine receptors site on the GABA/benzodiazepine receptor complex. It can also reverse the binding of benzodiazepines to benzodiazepine receptors.

How quickly does flumazenil work?

Eighty percent response will be reached within 3 minutes, with the peak effect occurring at 6 to 10 minutes. The duration and degree of reversal are related to the plasma concentration of the sedating benzodiazepine as well as the dose of flumazenil given.

How much flumazenil do I take?

The recommended initial dose of Flumazenil is 0.3 mg i.v. If the required level of consciousness is not obtained within 60 seconds, a further dose of 0.1 mg can be injected and repeated at 60-second intervals, up to a total dose of 2 mg or until the patient awakes.

What is metoclopramide used for?

It works by increasing the movements or contractions of the stomach and intestines. It relieves symptoms such as nausea, vomiting, heartburn, a feeling of fullness after meals, and loss of appetite. Metoclopramide is also used to treat heartburn for patients with gastroesophageal reflux disease (GERD).

When should I take flumazenil?

Flumazenil injection is indicated for the complete or partial reversal of the sedative effects of benzodiazepines in cases where general anesthesia has been induced and/or maintained with benzodiazepines, where sedation has been produced with benzodiazepines for diagnostic and therapeutic procedures, and for the

Does flumazenil reverse respiratory depression?

Flumazenil has been shown to be effective in reversing benzodiazepine-induced sedation, but its ability to reverse benzodiazepine-induced respiratory depression is controversial. When benzodiazepine-induced respiratory depression was evident, the ability of flumazenil to reverse it was inconsistent and short-lived.

Is midazolam a benzo?

Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. It belongs to a class of drugs called benzodiazepines. This drug is unique from others in this class due to its rapid onset of effects and short duration of action.

Is flumazenil a controlled drug?

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Although flumazenil has a benzodiazepine-like structure it does not act as a benzodiazepine agonist in man and is not a controlled substance.

What is the antidote for Ativan?

Flumazenil (Romazicon®) is the antidote for benzodiazepines, such as diazepam (Valium®), lorazepam (Ativan®), and midazolam (Versed®), and must be administered intravenously. Flumazenil (Romazicon®) is the reversal agent of choice for an overdose of benzodiazepines (diazepam or midazolam).

What drug reverses benzodiazepines?

Naloxone is used to reverse the effects of opiates while flumazenil is used to reverse the effects of benzodiazepines.

What medication reverses benzodiazepines?

Flumazenil is a benzodiazepine antagonist that can reverse the effects of benzodiazepines, although its use following benzodiazepine overdose is controversial.

What is the half life of flumazenil?

Flumazenil is extensively distributed in the extravascular space with an initial distribution half-life of 4 to 11 minutes and a terminal half-life of 40 to 80 minutes. Peak concentrations of flumazenil are proportional to dose, with an apparent initial volume of distribution of 0.5 L/kg.

What drugs are used to reverse anesthesia?

Intravenous reversal agents
  • Flumazenil, reverses the effects of benzodiazepines.
  • Naloxone, reverses the effects of opioids.
  • Neostigmine, helps reverse the effects of non-depolarizing muscle relaxants.
  • Sugammadex, new agent that is designed to bind Rocuronium therefore terminating its action.