Health & Fitness

What causes Adie's syndrome?

By: Nicole PhibsUpdated: December 06, 2020


Site Statistics

  • Questions
  • Answers
  • Categories
  • Last Updated
    September 26, 2022
In most instances, the exact cause of Adie syndrome is unknown (idiopathic). It is believed that most cases result from inflammation or damage to the ciliary ganglion, a cluster of nerve cells found in the eye socket (orbit) just behind the eyes, or damage to the post-ganglionic nerves.

Similarly, it is asked, does Adie Pupil go away?

For instance, the loss of tendon reflexes tends to progress, and this is permanent. While the pupil of the affected eye is generally larger when the person is younger, the affected pupil may shrink as the person ages. Older people with Adie syndrome may have a much smaller pupil in their affected eye.

Similarly, what does a tonic pupil mean?

The tonic pupil, sometimes called Adie tonic pupil or simply the Adie pupil, is the term used to denote a pupil with parasympathetic denervation that constricts poorly to light but reacts better to accommodation (near response), such that the initially larger Adie pupil becomes smaller than its normal fellow and

Can Adie's pupil cause headaches?

In the majority of people with Adie syndrome, the affected pupil is larger than usual all the time and does not constrict very much or at all in response to light stimulation. Most people with Adie syndrome have poor or absent reflexes as well. Other symptoms a person with this syndrome may experience include: Headache.

What are the 3 classic signs of Horner's syndrome?

Common signs and symptoms include:
  • A persistently small pupil (miosis)
  • A notable difference in pupil size between the two eyes (anisocoria)
  • Little or delayed opening (dilation) of the affected pupil in dim light.
  • Drooping of the upper eyelid (ptosis)
  • Slight elevation of the lower lid, sometimes called upside-down ptosis.


What is Adie's syndrome?

Adie syndrome, or Holmes-Adie syndrome, is a rare neurological disorder affecting the pupil of the eye. When only abnormalities affecting the pupil are present, the disorder may be referred to as Adie's pupil, Adie's tonic pupil or, most commonly, tonic pupil.

Should I be worried if one pupil is bigger than the other?

If a person's pupils are suddenly different sizes, it is best to seek medical attention. While not always harmful, a sudden change can indicate serious and dangerous medical conditions. It is especially important to seek medical attention if the change occurs after an injury or with other symptoms.

How common is Adie's pupil?

Young adults usually between the ages of 25 to 45 are most commonly affected. The prevalence of Adie's pupil (not the full syndrome) is approximately 2 people per 1,000 in the general population.

When should I be concerned about dilated pupils?

Brain Injury or Disease
One or both of your pupils can become fixed in the dilated position and can't react to light. If that happens, you should see a doctor right away. If you've had a head injury, your doctor or nurse might shine a light into your eye during the exam to see if your pupils get smaller.

Is Adie's pupil hereditary?

Cause. The loss of deep tendon reflexes in Adie syndrome is believed to be caused by damage to the dorsal root ganglion, a cluster of nerve cells in the root of the spinal nerves. In rare cases, Adie syndrome may be inherited . In these cases, it appears to follow an autosomal dominant pattern of inheritance.

What drugs cause dilated pupils?

Drugs and medications that can cause dilated pupils are:
  • Methamphetamines and other amphetamines.
  • Antihistamines (Including cold and allergy medications)
  • Atropine.
  • Pseudoephedrine (Sudafed)
  • Cocaine.
  • Marijuana.
  • LSD.
  • Heroin withdrawal.

Why is one eye dilated and the other not?

Anisocoria is a condition in which the pupil of one eye differs in size from the pupil of the other eye. Yourpupils are the black circles in the center of your eyes. They are usually the same size. Anisocoria can be caused by several things.

What causes pupils to be dilated all the time?

Causes. Several different medications can cause mydriasis in one or both eyes. Antihistamines, botox, muscle relaxants, and drugs used to treat Parkinson's disease may all cause the pupils to dilate. Recreational drugs that include cocaine, LSD, ecstasy, and amphetamines can also cause dilated pupils.

What nerve is damaged in Horner's syndrome?

It is caused by damage to the sympathetic nerves of the face. The underlying causes of Horner's syndrome vary greatly and may include a tumor , stroke, injury, or underlying disease affecting the areas surrounding the sympathetic nerves.

What is it called when one pupil is larger than the other?

Anisocoria is a condition in which the pupil of one eye differs in size from the pupil of the other eye. Yourpupils are the black circles in the center of your eyes. They are usually the same size. Anisocoria can be caused by several things.

What is light near dissociation?

Description. Light-near dissociation (LND) is a pupillary sign that occurs when the pupillary light reaction is impaired while the near reaction (accommodative response) remains intact.

Can your pupil move?

When the pupil briefly moves right-of-center, for example, the iris tissue to the right is slightly compressed, and the tissue to the left is slightly stretched. (Of course, the pupil is empty space, so it doesn't actually push on the tissue; it's motion is a result of the iris's inertia.)

Is unequal pupil size an emergency?

Uneven pupil size, or anisocoria, may be a normal variation in a person's eyes or may indicate an underlying problem. For new uneven pupil size that is related to new double vision, eyelid droopiness or head, neck or eye pain, it is best to be evaluated in the emergency room.