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DESCRIPTION: XELODA (capecitabine) is a fluoropyrimidine carbamate with antineoplastic activity. It is an orally administered systemic prodrug of 5'-deoxy-5-fluorouridine (5'-DFUR) which is converted to 5-fluorouracil. CLINICAL PHARMACOLOGY: Capecitabine is relatively non-cytotoxic in vitro.
In this way, what drugs are in 5fu?
Fluorouracil (5FU) Fluorouracil (5FU) is a chemotherapy drug used to treat different cancers including breast, bowel, skin, stomach, oesophageal (gullet), and pancreatic cancer.
One may also ask, what is irinotecan based chemotherapy?
Chemocare.com uses generic names in all descriptions of drugs. Camptosar is the trade name for irinotecan. Camptothecin-11 and CPT-11 are other names for irinotecan. Drug type: Irinotecan is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug.
What does Folfiri mean?
FOLinic acid-Fluorouracil-IRInotecan regimen. Abbreviation: FOLFIRI.
What are the side effects of capecitabine?
Side Effects. Nausea, vomiting, loss of appetite, constipation, tiredness, weakness, headache, dizziness, trouble sleeping, or changes in taste may occur. Nausea and vomiting can be severe. In some cases, your doctor may prescribe medication to prevent or relieve nausea and vomiting.
Related
Is capecitabine cytotoxic?
Capecitabine is the generic name for the trade name drug Xeloda. In some cases, health care professionals may use the trade name Xeloda when referring to the generic drug name capecitabine. Drug Type: Capecitabine is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug.
What is fluoropyrimidine based chemotherapy?
fluoropyrimidine (FLOOR-oh-py-RIH-mih-deen) One of a group of substances used to treat cancer. A fluoropyrimidine is a type of antimetabolite. Examples are capecitabine, floxuridine, and fluorouracil (5-FU).
What is the half life of capecitabine?
After oral administration of 1250 mg/m2, capecitabine is rapidly and extensively absorbed from the gastrointestinal tract [with a time to reach peak concentration (tmax) of 2 hours and peak plasma drug concentration (Cmax) of 3 to 4 mg/L] and has a relatively short elimination half-life (t(1/2)) [0.55 to 0.89 h].
What is folfox used for?
NCI Dictionary of Cancer Terms. An abbreviation for a combination chemotherapy regimen that is used to treat colorectal cancer. It includes the drugs leucovorin calcium (folinic acid), fluorouracil, and oxaliplatin.
How long has Xeloda been on the market?
Capecitabine was patented in 1992 and approved for medical use in 1998. It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system. The wholesale cost in the developing world is about US$122.64–195.66 per cycle of medication.
What is capecitabine made from?
The peach or light peach film coating contains hydroxypropyl methylcellulose, talc, titanium dioxide, and synthetic yellow and red iron oxides. CLINICAL PHARMACOLOGY: Capecitabine is relatively non-cytotoxic in vitro. This drug is enzymatically converted to 5-fluorouracil (5-FU) in vivo.
Is capecitabine a prodrug?
Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue.
Who makes capecitabine?
Genentech: Xeloda® (capecitabine) - Information for Patients.
Is 5fu a strong chemo drug?
Fluorouracil (5FU) is a chemotherapy drug used to treat different cancers including breast, bowel, skin, stomach, oesophageal (gullet), and pancreatic cancer.
How long can you take 5 Fu?
You usually have fluorouracil as part of a course of several cycles of treatment. You generally have up to 6 cycles of treatment. Each cycle lasts 2, 3 or 4 weeks. You have continuous treatment through a small portable pump.
What is the most toxic chemotherapy drug?
Doxorubicin (Adriamycin) is one of the most powerful chemotherapy drugs ever invented. It can kill cancer cells at every point in their life cycle, and it's used to treat a wide variety of cancers. Unfortunately, the drug can also damage heart cells, so a patient can't take it indefinitely.
How do you know when to stop fluorouracil?
During the first few weeks of treatment, the skin lesions and surrounding areas will feel irritated and look red, swollen, and scaly. This is a sign that fluorouracil is working. Do not stop using fluorouracil unless your doctor has told you to do so.
Do you lose your hair with 5fu?
Your hair may become thin, brittle, or may fall out. This typically begins two to three weeks after treatment starts. This hair loss can be all body hair, including pubic, underarm, legs/arms, eyelashes, and nose hairs. Hair generally starts to regrow soon after treatment is completed.
Does 5fu cause heart problems?
Heart Conditions Linked. Although rare, some people may have side effects linked to 5FU or capecitabine chemotherapies that affect their hearts. Up to 6 people out of 100 patients receiving this treatment have cardiac side effects. While some people have no symptoms, others might feel a chest pressure or pain.
What are the side effects of fluorouracil 5% cream?
Side Effects. Skin irritation, burning, redness, dryness, pain, swelling, tenderness, or changes in skin color may occur at the site of application. Eye irritation (e.g., stinging, watering), trouble sleeping, irritability, temporary hair loss, or abnormal taste in the mouth may also occur.
What should patients using 5 FU expect with treatment?
Fluorouracil (5FU) is a chemotherapy drug used to treat different cancers including breast, bowel, skin, stomach, oesophageal (gullet), and pancreatic cancer.
Symptoms of a blood clot include:
Symptoms of a blood clot include:
- pain, redness or swelling in a leg or arm.
- breathlessness.
- chest pain.